I've always had an appreciation for Kristen Wiig. I can't stand SNL but I think she's great. I think she's a much better actress than most people will give her credit for.
But, I don't think I could take her seriously as a villain. Soon we might have to see it happen. According to reports, Wiig is in talks to play a villain in the upcoming Wonder Woman 2.
I'd have a hard time seeing her as anything other than her comedic roles.